Talk by Sarah Köster – Københavns Universitet

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Talk by Sarah Köster

Biological matter – ranging from whole cells down to cellular components such as proteins – is governed by nanometer length scales. X-ray scattering and diffraction techniques are extremely well suited to study such systems as the spatial resolution extends well into the relevant length scales. At the same time, the investigation of biological systems requires well-defined and controllable sample environments. One way to establish such environments is by employing microfluidic devices tailored for the particular experiment. The combination of both microfluidics and X-ray micro-/nano-diffraction provides an innovative tool for biomatter research. Two particular examples will be shown. (i) The biomolecular assembly of proteins is studied in vitro by diffusively mixing in assembly buffer and following the subsequent assembly steps downstream in the flow channel. (ii) Cells are imaged on the nanometer scale by scanning x-ray diffraction using a nanometer-focused beam.

Sarah Köster is professor and group-leader in the Physics Department at University of Göttingen, Germany. Her research combines advanced microfluidics techniques, imaging incl. x-ray based imaging to investigate the nano and microstructure of biological systems.