Yale Center for High Throughput Cell Biology


Yale has successfully implemented a high through-put suite with the capacity to run  biochemical assays as well as complex cell based assays. Our automation suite includes imaging platforms of two kinds, a high content confocal microscopy unit (Opera as well as Ultraview) and integrated plate readers with a broad spectrum of detection capabilities. The flexibility and capacity of the Yale automation platforms combined with a BSL2+ environment enables us not only to screen assays of many different types at a high pace but also accommodate assays incorporating toxins and patogens up to BSL2+. Our extensive suite of over 180 cell based assays are all compatible with our automation platform and detection systems. This enables us to implement a high through-put approach to extensive secondary assay analysis of compounds identified both in our own screens and referred to us from other centers. The combined strength of phenotypic assays describing complex biological processes and extensive annotation of the assays, enables a deep understanding of mechanism of action of compounds analyzed against our set of assays. We are now in the process of constructing an expert system/database/pointer tree hybrid for both the analysis of the biological profiling data as well as to enable dynamic population/retraction/re-population of the complex data sets necessary to extract biologically significant data from extensive high content cell based assay profiling.”


Lars J. Branden, PhD, Director of LaB Enterprises

Lead scientist, team manager, program director, entrepreneur and teacher with broad scientific background, including expertise in developing high content cell based assays for high throughput screening, gene delivery techniques, and virology. Extensive experience in the areas of automated microscopy, image analysis, automation and custom-made cell culture systems. Additional expertise in Molecular Biology, Cellular Biology and Biochemistry. Successful in team-building and direct research teams to reach goals and milestones. Creative approach in developing new technologies and new applications. Strong background in design, implementation, and applications development for new technology. Extensive teaching experience in various fields such as gene mapping, applied virology, digital microscopy and gene therapy.
 
Source: http://www.labenterprises.net/

How to get to the auditorium

 

Contact:  Vivian Henningsen  (Vivian.henningsen@cpr.ku.dk)
  Tel. +45 3532-6762